Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes

Title:Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes

Volume: 23 Issue: 1

Author(s): Karmen Stankov, Suncica Stankov and Jasmina Katanic

Affiliation:

Keywords: Myelodysplastic syndromes, leukemia, mutations, epigenetic targets, pathogenesis, therapy, hypomethylating agents, microRNA.

Abstract: Background: Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal disorders of hematopoietic system, characterized by genetic, epigenetic or microenvironmental alterations of aging hematopoietic stem cells. Pathophysiology of MDS comprises the suppression of normal hematopoiesis and reduced myeloid progenitor cells differentiation, with the main consequence of peripheral cytopenias and increased risk to evolution in acute myeloid leukemia (AML).

Method: This review summarizes the evolving understanding of the role of genetic and epigenetic alterations involved in pathogenesis and current and future strategies for therapeutic targeting in myelodysplastic syndromes.

Results: In addition to molecular characteristics, immune and microenvironmental factors in bone marrow of MDS patients may further modify the MDS manifestations, its clinical presentation, disease course, risk of transformation to AML and prognosis of MDS, as well as response to therapy. Current clinical response to therapy approaches are exerted both by epigenetic alterations and by induction of apoptosis.

Conclusion: Future treatment strategies in preclinical and clinical investigations are directed towards new dosing schedules of existing drugs, new genetic and epigenetic targets and combination of different agents, including hypomethylation agents and histone deacetylase inhibitors.

Cite this article as:

Stankov Karmen, Stankov Suncica and Katanic Jasmina, Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes, Current Pharmaceutical Design 2017; 23 (1) . https://dx.doi.org/10.2174/1381612822666161003160033

DOI https://dx.doi.org/10.2174/1381612822666161003160033	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286