Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans

Title:Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans

Volume: 10 Issue: 6

Author(s): Konstantinos Daniilides, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Pinelopi Samara and Ourania Tsitsilonis

Affiliation:

Keywords: Benzofurans, Cytotoxicity, Heterocycles, Sonogashira cross-coupling, Wadsworth-Emmons reaction.

Abstract: A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-activity relationships.

Cite this article as:

Daniilides Konstantinos, Lougiakis Nikolaos, Pouli Nicole, Marakos Panagiotis, Samara Pinelopi and Tsitsilonis Ourania, Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans, Medicinal Chemistry 2014; 10 (6) . https://dx.doi.org/10.2174/15734064113096660049