Abstract
This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters
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