Synthesis and Antihypertensive Activity of Novel Quinazolin-4(3H)-one Derivatives

Title:Synthesis and Antihypertensive Activity of Novel Quinazolin-4(3H)-one Derivatives

Volume: 14 Issue: 1

Author(s): Seema R. Pathak, Vineet Malhotra, Rajendra Nath and Kripa Shanker

Affiliation:

Keywords: Antihypertensive, alpha adrenoceptors, bradycardia, ALD50, N, N’ dimethyl amine, NE response, piperazine, quinazolinone.

Abstract: A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg).

Cite this article as:

Pathak R. Seema, Malhotra Vineet, Nath Rajendra and Shanker Kripa, Synthesis and Antihypertensive Activity of Novel Quinazolin-4(3H)-one Derivatives, Central Nervous System Agents in Medicinal Chemistry 2014; 14 (1) . https://dx.doi.org/10.2174/1871524914666140825144729