Abstract
The design of neurorehabilitation therapy to treat subjects with altered consciousness provides opportunities and challenges to professionals involved with the care for these severely ill patients. While there is an increased interest in determining methods to restore consciousness in these patients, the process is complex and challenging, due in part to the diverse aetiology of these states of consciousness, and also to the intricate cerebral connectivity involved in their treatment. The present case study examines a patient who showed signs of emergence from the vegetative state after neurorehabilitation using The Combined Method Therapy (CMT). In this case, neurorehabilitation therapy was applied simultaneously with pharmacological treatment, stimulation, and neuroimaging techniques to help adjust drug dosage. The results of this study suggest that this combined approach to treatment promoted connectivity among posterior and anterior cortical regions aiding emergence from the vegetative state.
Keywords: Vegetative state, severe neurocognitive disorder, consciousness, minimally conscious state, QEEG.
Current Pharmaceutical Design
Title:Restoring Cortical Connectivity Directionality and Synchronization is Essential to Treating Disorder of Consciousness
Volume: 20 Issue: 26
Author(s): Jose Leon-Carrion, Umberto Leon-Dominguez, James Halper, Luca Pollonini, George Zouridakis and Maria del Rosario Domínguez-Morales
Affiliation:
Keywords: Vegetative state, severe neurocognitive disorder, consciousness, minimally conscious state, QEEG.
Abstract: The design of neurorehabilitation therapy to treat subjects with altered consciousness provides opportunities and challenges to professionals involved with the care for these severely ill patients. While there is an increased interest in determining methods to restore consciousness in these patients, the process is complex and challenging, due in part to the diverse aetiology of these states of consciousness, and also to the intricate cerebral connectivity involved in their treatment. The present case study examines a patient who showed signs of emergence from the vegetative state after neurorehabilitation using The Combined Method Therapy (CMT). In this case, neurorehabilitation therapy was applied simultaneously with pharmacological treatment, stimulation, and neuroimaging techniques to help adjust drug dosage. The results of this study suggest that this combined approach to treatment promoted connectivity among posterior and anterior cortical regions aiding emergence from the vegetative state.
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Leon-Carrion Jose, Leon-Dominguez Umberto, Halper James, Pollonini Luca, Zouridakis George and Domínguez-Morales del Rosario Maria, Restoring Cortical Connectivity Directionality and Synchronization is Essential to Treating Disorder of Consciousness, Current Pharmaceutical Design 2014; 20 (26) . https://dx.doi.org/10.2174/13816128113196660651
DOI https://dx.doi.org/10.2174/13816128113196660651 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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