Abstract
A novel and facile Biginelli-like assembly employing enaminones, aldehydes and 3-amino-1,2,4-triazole has been developed, which provides a novel synthesis of new 5-unsubstituted-6-aroyl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.
Keywords: 3-amino-1, 2, 4-triazole, enamines, Biginelli-like, 6-Aroyl-[1, 2, 4]triazolo[1, 5-a]pyrimidine, pyrimidine-2-thione, 4-aryl-7-thioxo- 3, 4, 7, 8-tetrahydropyrimido[4, 5-d]pyrimidine-2, 5(1H, 6H)-dione.
Current Organic Synthesis
Title:One-Pot Synthesis of 5-Unsubstituted-6-Aroyl[1,2,4]triazolo[1,5-a]pyrimidine Utilizing Biginelli-Like Multicomponent Reaction of Enaminones with 3-Amino-1,2,4- triazole as the Urea Component
Volume: 10 Issue: 6
Author(s): Huwaida M.E. Hassaneen and Ismail A. Abdelhamid
Affiliation:
Keywords: 3-amino-1, 2, 4-triazole, enamines, Biginelli-like, 6-Aroyl-[1, 2, 4]triazolo[1, 5-a]pyrimidine, pyrimidine-2-thione, 4-aryl-7-thioxo- 3, 4, 7, 8-tetrahydropyrimido[4, 5-d]pyrimidine-2, 5(1H, 6H)-dione.
Abstract: A novel and facile Biginelli-like assembly employing enaminones, aldehydes and 3-amino-1,2,4-triazole has been developed, which provides a novel synthesis of new 5-unsubstituted-6-aroyl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.
Export Options
About this article
Cite this article as:
Hassaneen M.E. Huwaida and Abdelhamid A. Ismail, One-Pot Synthesis of 5-Unsubstituted-6-Aroyl[1,2,4]triazolo[1,5-a]pyrimidine Utilizing Biginelli-Like Multicomponent Reaction of Enaminones with 3-Amino-1,2,4- triazole as the Urea Component, Current Organic Synthesis 2013; 10 (6) . https://dx.doi.org/10.2174/15701794113109990065
DOI https://dx.doi.org/10.2174/15701794113109990065 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Spices Chemoconstituents as Persuasive Inhibitor of S. typhimurium Virulent Protein L-asparaginase
Letters in Drug Design & Discovery Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
Current Drug Safety Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation
Medicinal Chemistry Design, Synthesis and In Vitro Biological Evaluation of Pyridine, Thiadazole, Benzimidazole and Acetyl Thiophene Analogues as Anti Tubercular Agents Targeting Enzyme Inh A
Current Computer-Aided Drug Design Evaluation of Substituted Benzaldehydes Against Mycobacterium tuberculosis
Letters in Drug Design & Discovery Approaches to Target Profiling of Natural Products
Current Medicinal Chemistry Self-assembled Antibiotic Nanoparticles Against Intracellular Bacteria
Drug Delivery Letters Estimation of Mortality from Vital Registrations in South Africa
Current HIV Research Smart Biodecorated Hybrid Nanoparticles
Current Bionanotechnology (Discontinued) The Interplay of Disease Modifying Anti Rheumatic Drugs and Tuberculin Skin Test
Current Reviews in Clinical and Experimental Pharmacology Molecular Biomarkers of Disease for Diagnosis and Drug Development
Current Medicinal Chemistry Armed Imidazo [1,2-a] Pyrimidines (Pyridines): Evaluation of Antibacterial Activity
Letters in Drug Design & Discovery Using Property Based Sequence Motifs and 3D Modeling to Determine Structure and Functional Regions of Proteins
Current Medicinal Chemistry The Role of Lymphotoxin Receptor Signaling in Diseases
Current Molecular Medicine Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective
Current Protein & Peptide Science Current Therapeutic Approaches in Inflammatory Bowel Disease
Current Pharmaceutical Design Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus
Current Signal Transduction Therapy Computational Simulations of the Immune System for Personalized Medicine: State of the Art and Challenges
Current Pharmacogenomics and Personalized Medicine Synthesis and SAR Studies of Urea and Thiourea Derivatives of Gly/Pro Conjugated to Piperazine Analogue as Potential AGE Inhibitors
Protein & Peptide Letters HLA-E and HLA-E-Bound Peptides: Recognition by Subsets of NK and T Cells
Current Pharmaceutical Design