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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

First Girgensohnine Analogs Prepared Through InCl3-catalyzed Strecker Reaction and their Bioprospection

Author(s): Leonor Y. Vargas Mendez and Vladimir V. Kouznetsov

Volume 10, Issue 6, 2013

Page: [969 - 973] Pages: 5

DOI: 10.2174/157017941006140206105449

Price: $65

Abstract

An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl3-catalyzed one-pot Strecker reaction, and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity.

Keywords: AChE inhibitory activity, alkaloids, α-Aminonitriles, antioxidant capacity, girgensohnine, Strecker reaction.


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