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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Natural and Synthetic Compounds with an Antimycobacterial Activity

Author(s): L. N. Rogoza, N. F. Salakhutdinov and G. A. Tolstikov

Volume 6, Issue 2, 2009

Page: [135 - 151] Pages: 17

DOI: 10.2174/157019309788167657

Price: $65

Abstract

This review discusses the most active natural and synthetic compounds demonstrating the antimycobacterial activity at minimum inhibiting concentrations (MIC) of 5 μg/ml or less. For better insight into the “structure-activity” relationships, we occasionally considered compounds with high values of MIC. The review covers the period from 2001 to 2007. The data are grouped according to chemical structures, namely, nitrogen-, oxygen-, and sulfur-containing heterocyclic compounds, peptide, alkaloids, terpenoids, and others.

Keywords: Tuberculosis, multidrug-resistance tuberculosis, M. tuberculosis, antimycobacterial activity, antituberculosis activity, cytotoxicity, “structure-activity” relationships


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