Vitamin D - Pivotal Nutraceutical in the Regulation of Cancer Metastasis and Angiogenesis

Title:Vitamin D - Pivotal Nutraceutical in the Regulation of Cancer Metastasis and Angiogenesis

Volume: 20 Issue: 33

Author(s): Jun Xu, Wei Li, Jiguang Ma, Jiangbo Liu, Huanchen Sha, Shuang Zhou, Fengfei Wang and Qingyong Ma

Affiliation:

Keywords: Angiogenesis, calcitriol, cancer prevention, epidemiology, epithelial-mesenchymal transition, metabolism, metastasis, synthesis, vitamin D, review.

Abstract: Various epidemiological studies have demonstrated that vitamin D may play important roles in the pathogenesis and progression of cancer. Vitamin D is one of the most pivotal nutraceuticals whose active metabolite, calcitriol (1,25-dihydroxyvitamin D₃), possesses anti-proliferative, pro-apoptotic, and pro-differentiating capabilities. Accumulating evidence indicates that the potential benefits of using vitamin D in cancer are not only anti-cancer cell proliferation which is linked with its anti-inflammatory effects, including the suppression of prostaglandin metabolism and inhibition of NF- B signaling, but also suppressing tumor metastasis and angiogenesis. Here, we present a systematic summary of the effects of vitamin D in the chemoprevention and chemotherapy of cancer, especially anti-metastatic and anti-angiogenic actions.

Cite this article as:

Xu Jun, Li Wei, Ma Jiguang, Liu Jiangbo, Sha Huanchen, Zhou Shuang, Wang Fengfei and Ma Qingyong, Vitamin D - Pivotal Nutraceutical in the Regulation of Cancer Metastasis and Angiogenesis, Current Medicinal Chemistry 2013; 20 (33) . https://dx.doi.org/10.2174/09298673113209990194