The Genetic Basis of Graves Disease

Title: The Genetic Basis of Graves Disease

Volume: 12 Issue: 8

Author(s): Rafal Ploski, Konrad Szymanski and Tomasz Bednarczuk

Affiliation:

Keywords: Graves' disease, thyroid, autoimmunity, association, HLA, non-HLA genes, PTPN22, CD40, TSHR, FCRL3

Abstract: The presented comprehensive review of current knowledge about genetic factors predisposing to Graves disease (GD) put emphasis on functional significance of observed associations. In particular, we discuss recent efforts aimed at refining diseases associations found within the HLA complex and implicating HLA class I as well as HLADPB1 loci. We summarize data regarding non-HLA genes such as PTPN22, CTLA4, CD40, TSHR and TG which have been extensively studied in respect to their role in GD. We review recent findings implicating variants of FCRL3 (gene for FC receptor-like-3 protein), SCGB3A2 (gene for secretory uteroglobin-related protein 1- UGRP1) as well as other unverified possible candidate genes for GD selected through their documented association with type 1 diabetes mellitus: Tenr – IL2 – IL21, CAPSL (encoding calcyphosine-like protein), IFIH1(gene for interferon-induced helicase C domain 1), AFF3, CD226 and PTPN2. We also review reports on association of skewed X chromosome inactivation and fetal microchimerism with GD. Finally we discuss issues of genotype-phenotype correlations in GD.

Cite this article as:

Ploski Rafal, Szymanski Konrad and Bednarczuk Tomasz, The Genetic Basis of Graves Disease, Current Genomics 2011; 12 (8) . https://dx.doi.org/10.2174/138920211798120772