Abstract
Reactive oxygen and nitrogen species play complex roles in the physiological regulation of cell metabolism and in many disease processes as well, including viral infections. Viral replication occurs within living cells and is totally dependent on its hosts biosynthetic machinery. Many intracellular signaling pathways exploited by viruses for their own replication are regulated by the oxidoreductive (redox) state of the host cell. Consequently, factors that alter the balance between reactive oxygen/nitrogen species and antioxidant molecules/enzymes-including metabolic conditions like malnutrition, obesity, and diabetes-can influence cells susceptibility to viral infection, the efficiency of viral replication, and as a result the progression and severity of virus-induced diseases. This review examines the ways in which the host-cell redox state affect viral replication and the actual potential of antioxidants to combat viral infections.
Keywords: Redox state, metabolism, viral infection, antioxidants, oxidative stress, apoptosis, proinflammatory cytokines, autophagosomes, diabetes mellitus, obesity
Current Pharmaceutical Design
Title: Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy
Volume: 17 Issue: 35
Author(s): Lucia Nencioni, Rossella Sgarbanti, Donatella Amatore, Paola Checconi, Ignacio Celestino, Dolores Limongi, Simona Anticoli, Anna Teresa Palamara and Enrico Garaci
Affiliation:
Keywords: Redox state, metabolism, viral infection, antioxidants, oxidative stress, apoptosis, proinflammatory cytokines, autophagosomes, diabetes mellitus, obesity
Abstract: Reactive oxygen and nitrogen species play complex roles in the physiological regulation of cell metabolism and in many disease processes as well, including viral infections. Viral replication occurs within living cells and is totally dependent on its hosts biosynthetic machinery. Many intracellular signaling pathways exploited by viruses for their own replication are regulated by the oxidoreductive (redox) state of the host cell. Consequently, factors that alter the balance between reactive oxygen/nitrogen species and antioxidant molecules/enzymes-including metabolic conditions like malnutrition, obesity, and diabetes-can influence cells susceptibility to viral infection, the efficiency of viral replication, and as a result the progression and severity of virus-induced diseases. This review examines the ways in which the host-cell redox state affect viral replication and the actual potential of antioxidants to combat viral infections.
Export Options
About this article
Cite this article as:
Nencioni Lucia, Sgarbanti Rossella, Amatore Donatella, Checconi Paola, Celestino Ignacio, Limongi Dolores, Anticoli Simona, Teresa Palamara Anna and Garaci Enrico, Intracellular Redox Signaling as Therapeutic Target for Novel Antiviral Strategy, Current Pharmaceutical Design 2011; 17 (35) . https://dx.doi.org/10.2174/138161211798357728
DOI https://dx.doi.org/10.2174/138161211798357728 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Prevalence of Pre-Existing Risk Factors for Adverse Events Associated with Atypical Antipsychotics Among Commercially Insured and Medicaid Insured Patients Newly Initiating Atypical Antipsychotics
Current Drug Safety Blood Pressure Lowering and Outcomes in type 2 Diabetes: Implications of the Blood Pressure-Lowering Arm of the Advance Trial
Current Hypertension Reviews Treatment of Early Vascular Ageing
Current Pharmaceutical Design An Angiotensin Converting Enzyme Inhibitor Suppresses Contrast Media Induced Renal Dysfunction in a Murine Model of Subtotal Nephrectomy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease
Current Medicinal Chemistry Insulin Treatment and Weight Gain in Type 2 Diabetes: Is Our Knowledge Complete?
Current Nutrition & Food Science The Role of Interleukin-6 in the Pathogenesis, Prognosis and Treatment of Severe COVID-19
Current Medicinal Chemistry Rheumatoid Arthritis: Notable Biomarkers Linking to Chronic Systemic Conditions and Cancer
Current Pharmaceutical Design Non-enzymatic Glycation of Almond Cystatin Leads to Conformational Changes and Altered Activity
Protein & Peptide Letters Protein Kinase C – Possible Therapeutic Target to Treat Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets Anesthesia Issues in Central Nervous System Disorders
Current Aging Science Treating Benign Prostatic Hyperplasia with Botulinum Neurotoxin
Current Medicinal Chemistry The Effect of Statin Therapy on Arterial Stiffness by Measuring Pulse Wave Velocity: A Systematic Review
Current Vascular Pharmacology Reactive Oxygen Species in Pathogenesis of Atherosclerosis
Current Pharmaceutical Design Modulation of Platelet Function and Signaling by Flavonoids
Mini-Reviews in Medicinal Chemistry Why Is Homocysteine Toxic for the Nervous and Immune Systems?
Current Aging Science High Sensitivity Troponin in Cardiovascular Disease. Is There More Than a Marker of Myocardial Death?
Current Topics in Medicinal Chemistry Hemodynamic Behavior of Coronary Stents in Straight and Curved Arteries
Current Nanoscience New Approved Medications for Idiopathic Pulmonary Fibrosis
Current Drug Therapy Effect of Homocysteinylation on Structure, Chaperone Activity and Fibrillation Propensity of Lens Alpha-crystallin
Protein & Peptide Letters