Exploring the Unexplored Practical and Alternative Synthesis of 3- (Trifluoromethyl)-Triazolopiperazine the Key Intermediate for Sitagliptin

Title:Exploring the Unexplored Practical and Alternative Synthesis of 3- (Trifluoromethyl)-Triazolopiperazine the Key Intermediate for Sitagliptin

Volume: 10 Issue: 5

Author(s): Lakshmikant H. Nitlikar, Sunil N. Darandale and Devanand B. Shinde

Affiliation:

Keywords: Sitagliptin, 3-(trifluoromethyl)-triazolopiperazine, 3-(trifluoromethyl)-triazolopyridine, antidiabetic.

Abstract: The practical synthesis of 3-(trifluoromethyl)-triazolopiperazine the key intermediate of Sitagliptin and 3- (trifluoromethyl)-triazolopyridine was carried out employing industrially feasible transformations. The other advantage of this method is the new environment friendly approach to synthesize triazolopiperazine and triazolopyridines by eliminating the commonly used trifluoroacetic anhydride and polyphosphoric acid.

Cite this article as:

Nitlikar Lakshmikant H., Darandale Sunil N. and Shinde Devanand B., Exploring the Unexplored Practical and Alternative Synthesis of 3- (Trifluoromethyl)-Triazolopiperazine the Key Intermediate for Sitagliptin, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050008