Abstract
Adrenocortical carcinoma (ACC) is a rare but typically aggressive malignancy. Radical surgery remains the potentially curative option. However, about one third of patients initially present with distant metastases. Regarding to chemotherapy, mitotane alone or in combination with cytotoxic drugs should be the first selection. Meanwhile, a phase lll clinical trial of etoposide, doxorubicin, cisplatin plus mitotane or streptozotocin plus mitotane is currently undergoing worldwide. The study on molecular pathogenesis of ACC is progressing. A lot of targeted therapies are also enrolled in preclinical investigations and clinical trials, including small-molecule tyrosine kinase inhibitors, antiangiogenic compounds. This article introduced the conventional chemotherapy, newly developed targeted therapy for advanced ACC.
Keywords: Advanced adrenocortical carcinoma, Chemotherapy, Mitotane, Molecular target, Target therapy
Anti-Cancer Agents in Medicinal Chemistry
Title:Conventional Chemotherapy and Emerging Targeted Therapy for Advanced Adrenocortical Carcinoma
Volume: 13 Issue: 2
Author(s): Yun-Ze Xu and Yu Zhu
Affiliation:
Keywords: Advanced adrenocortical carcinoma, Chemotherapy, Mitotane, Molecular target, Target therapy
Abstract: Adrenocortical carcinoma (ACC) is a rare but typically aggressive malignancy. Radical surgery remains the potentially curative option. However, about one third of patients initially present with distant metastases. Regarding to chemotherapy, mitotane alone or in combination with cytotoxic drugs should be the first selection. Meanwhile, a phase lll clinical trial of etoposide, doxorubicin, cisplatin plus mitotane or streptozotocin plus mitotane is currently undergoing worldwide. The study on molecular pathogenesis of ACC is progressing. A lot of targeted therapies are also enrolled in preclinical investigations and clinical trials, including small-molecule tyrosine kinase inhibitors, antiangiogenic compounds. This article introduced the conventional chemotherapy, newly developed targeted therapy for advanced ACC.
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Cite this article as:
Xu Yun-Ze and Zhu Yu, Conventional Chemotherapy and Emerging Targeted Therapy for Advanced Adrenocortical Carcinoma, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1871520611313020010
DOI https://dx.doi.org/10.2174/1871520611313020010 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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