Prevalence and Distribution of Human Papillomavirus Genotype in South Eastern Italy, in the Period 2006-2011: Implications for Intervention

Title:Prevalence and Distribution of Human Papillomavirus Genotype in South Eastern Italy, in the Period 2006-2011: Implications for Intervention

Volume: 19 Issue: 8

Author(s): Marcello Guido, Andrea Tinelli, Antonella De Donno, Anna Rita Bruno, Luigi Tagliaferro, Alberto Fedele, Aniello Carbone, Paola Menegazzi, Valerio Aprile, Marilena Greco, Antonio Malvasi, Maria Antonietta Piccinni, Silvio Turano, Pierfrancesco Grima, Domenico Dell'Ederam and Antonella Zizza

Affiliation:

Keywords: Human papillomavirus, prevalence, HPV genotyping, Clinic-based surveillance, HPV vaccine, Southern Italy, infection, cervical cancer, revention methods, HPV vaccination programs

Abstract: Persistent infection of High Risk (HR) Human papillomavirus (HPV) infection can lead to cervical cancer. The HPV genotypes are found worldwide, but important regional variations have been found. For a population-based HPV type prevalence study to assess the effect of existing and new prevention methods, frequently updated information on the burden of cervical cancer is essential.

We evaluated the prevalence of HPV genotypes in a volunteer population screened for cervical cancer at the Local Health Unit (LHU) of Lecce. A total of 9,720 women were studied. The tests were performed by INNO-Lipa HPV Genotyping and LINEAR ARRAY HPV Genotyping Test. The overall HPV prevalence was 29.7% (95% CI, 28.8-30.6) for any HPV DNA. The prevalent type for all age groups was HPV 16 (7.4%; CI, 6.9-7.9) followed by HPV 31 (3.4%; CI, 3.0-3.7), 51 (3.0%; CI, 2.6-3.3), 52 (2.7%; CI, 2.3-3.0) and 58 (2.4%; CI, 2.1-2.7). HPV 53 was the most common low-risk HPV type with prevalence rate of 3.5 (CI, 3.1-3.8), followed by HPV 66 (3.0; CI, 2.6-3.3), 6 (2.9; CI, 2.6-3.2) and 42 (2.5; CI, 2.2-2.8). Multiple infections were present in 13.6% of HPV-tested women (CI, 12.9-14.3). Among these, the most common combination was of HPV 16 and HPV 52 genotypes.

This study reports high prevalence of HPV infection and may serve as a valuable reference for assessing the impact of HPV vaccination programs. Furthermore, it supports the need for new vaccines that contain the most common HPV genotypes present in the population.

Cite this article as:

Guido Marcello, Tinelli Andrea, De Donno Antonella, Rita Bruno Anna, Tagliaferro Luigi, Fedele Alberto, Carbone Aniello, Menegazzi Paola, Aprile Valerio, Greco Marilena, Malvasi Antonio, Antonietta Piccinni Maria, Turano Silvio, Grima Pierfrancesco, Dell'Ederam Domenico and Zizza Antonella, Prevalence and Distribution of Human Papillomavirus Genotype in South Eastern Italy, in the Period 2006-2011: Implications for Intervention, Current Pharmaceutical Design 2013; 19 (8) . https://dx.doi.org/10.2174/1381612811319080017