Abstract
Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca2+ release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies. These discoveries have led to the development of novel drugs, screening tools, and research methods. The patents associated with these advances tell the story of the initial discovery of RyRs as a target for plant alkaloids, to their central role in cardiac and skeletal muscle excitation-contraction coupling, and ongoing clinical trials with a novel class of drugs called RycalsTM that inhibit pathological intracellular Ca2+ leak. Additionally, these patents highlight questions, controversies, and future directions of the RyR field.
Keywords: Ryanodine, calcium, EC-coupling, myocardium, skeletal muscle, sarcoplasmic reticulum (SR), calcium leakage, leaky SR, Rycal, JTV519, S107, heart failure, malignant hyperthermia, arrhythmias, patents
Recent Patents on Biotechnology
Title:Ryanodine Receptor Patents
Volume: 6 Issue: 3
Author(s): Alexander Kushnir and Andrew R. Marks
Affiliation:
Keywords: Ryanodine, calcium, EC-coupling, myocardium, skeletal muscle, sarcoplasmic reticulum (SR), calcium leakage, leaky SR, Rycal, JTV519, S107, heart failure, malignant hyperthermia, arrhythmias, patents
Abstract: Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca2+ release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies. These discoveries have led to the development of novel drugs, screening tools, and research methods. The patents associated with these advances tell the story of the initial discovery of RyRs as a target for plant alkaloids, to their central role in cardiac and skeletal muscle excitation-contraction coupling, and ongoing clinical trials with a novel class of drugs called RycalsTM that inhibit pathological intracellular Ca2+ leak. Additionally, these patents highlight questions, controversies, and future directions of the RyR field.
Export Options
About this article
Cite this article as:
Kushnir Alexander and R. Marks Andrew, Ryanodine Receptor Patents, Recent Patents on Biotechnology 2012; 6 (3) . https://dx.doi.org/10.2174/1872208311206030157
DOI https://dx.doi.org/10.2174/1872208311206030157 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
3D Cell and Scaffold Patterning Strategies in Tissue Engineering
Recent Patents on Biomedical Engineering (Discontinued) Heart Disease Prediction System Using Decision Tree and Naive Bayes Algorithm
Current Medical Imaging Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure
Current Vascular Pharmacology Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Transplantation of Adipose Tissue-Derived Stem Cells for Treatment of Focal Cerebral Ischemia
Current Neurovascular Research Inflammatory Arthritis and Heart Disease
Current Pharmaceutical Design Platelet Turnover in Atherothrombotic Disease
Current Pharmaceutical Design Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis
Current Topics in Medicinal Chemistry Antioxidant Activity of Resveratrol Analogs
Letters in Drug Design & Discovery Age-related Changes in Pharmacodynamics: Focus on Drugs Acting on Central Nervous and Cardiovascular Systems
Current Drug Metabolism Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators
Current Vascular Pharmacology Insulin Resistance in Nonalcoholic Fatty Liver Disease
Current Pharmaceutical Design Endothelial Dysfunction Induced by Cadmium and Mercury and its Relationship to Hypertension
Current Hypertension Reviews The Pathophysiological Basis of Carotid Baroreceptor Stimulation for the Treatment of Resistant Hypertension
Current Vascular Pharmacology Obesity-Driven Inflammation and Colorectal Cancer
Current Medicinal Chemistry Artificial Intelligence Approaches for Rational Drug Design and Discovery
Current Pharmaceutical Design Fetal Mechanisms That Lead to Later Hypertension
Current Drug Targets Gene Expression Analysis Approach to Establish Possible Links Between Parkinson's Disease, Cancer and Cardiovascular Diseases
CNS & Neurological Disorders - Drug Targets Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Role of Mediterranean Diet, CoQ10 and Conjugated-Melatonin in Osteoporosis Primary Prevention and Therapy
Current Nutrition & Food Science