An Emerging Antiarrhythmic Target: Late Sodium Current

Title:An Emerging Antiarrhythmic Target: Late Sodium Current

Volume: 21 Issue: 8

Author(s): T. Banyasz, N. Szentandrassy, J. Magyar, Z. Szabo, P.P. Nanasi, Y. Chen-Izu and L.T. Izu

Affiliation:

Keywords: Late sodium current, cardiac sodium channel, arrhythmias.

Abstract: The cardiac late sodium current (I_Na,L) has been in the focus of research in the recent decade. The first reports on the sustained component of voltage activated sodium current date back to the seventies, but early studies interpreted this tiny current as a product of a few channels that fail to inactivate, having neither physiologic nor pathologic implications. Recently, the cardiac I_Na,L has emerged as a potentially major arrhythmogenic mechanism in various heart diseases, attracting the attention of clinicians and researchers. Research activity on I_Na,L has exponentially increased since Ranolazine, an FDA-approved antianginal drug was shown to successfully suppress cardiac arrhythmias by inhibiting I_Na,L. This review aims to summarize and discuss a series of papers focusing on the cardiac late sodium current and its regulation under physiological and pathological conditions. We will discuss critical evidences implicating I_Na,L as a potential target for treating myocardial dysfunction and cardiac arrhythmias.

Cite this article as:

Banyasz T., Szentandrassy N., Magyar J., Szabo Z., Nanasi P.P., Chen-Izu Y. and Izu L.T., An Emerging Antiarrhythmic Target: Late Sodium Current, Current Pharmaceutical Design 2015; 21 (8) . https://dx.doi.org/10.2174/1381612820666141029111729