Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities

Title:Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities

Volume: 12 Issue: 14

Author(s): Jose J. Reina and Anna Bernardi

Affiliation:

Keywords: Carbohydrates, glycomimetics, C-type lectins and DC-SIGN, Pseudomonas aeruginosa, LECTINS, carbohydrate-encoded, high-mannose, oligosaccharides

Abstract: Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others’ studies on the dendritic cell receptor DC-SIGN are illustrated.

Cite this article as:

J. Reina Jose and Bernardi Anna, Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832690