Abstract
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
Keywords: Inflammation, aging, centenarians, cell senescence, immunosenescence, immunological stimuli, pro-inflammatory mediators, markers, inflamm-aging, longevity
Current Pharmaceutical Design
Title:Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised
Volume: 19 Issue: 9
Author(s): Annalaura Barbieri, Claudio Franceschi, Miriam Capri, Aurelia Santoro, Fiammetta Biondi, Maria Scurti, Elisa Pini, Elisa Cevenini, Morena Martucci, Elena Bellavista, Dario Vianello, Vincenzo Borelli, Laura Lomartire, Stefano Salvioli, Stella Lukas Yani, Federica Sevini, Laura Bucci, Rita Ostan, Elisa Fontanesi, Cristina Giuliani, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Maria Conte, Catia Lanzarini and Daniela Monti
Affiliation:
Keywords: Inflammation, aging, centenarians, cell senescence, immunosenescence, immunological stimuli, pro-inflammatory mediators, markers, inflamm-aging, longevity
Abstract: Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
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Barbieri Annalaura, Franceschi Claudio, Capri Miriam, Santoro Aurelia, Biondi Fiammetta, Scurti Maria, Pini Elisa, Cevenini Elisa, Martucci Morena, Bellavista Elena, Vianello Dario, Borelli Vincenzo, Lomartire Laura, Salvioli Stefano, Lukas Yani Stella, Sevini Federica, Bucci Laura, Ostan Rita, Fontanesi Elisa, Giuliani Cristina, Garagnani Paolo, Giulia Bacalini Maria, Pirazzini Chiara, Conte Maria, Lanzarini Catia and Monti Daniela, Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised, Current Pharmaceutical Design 2013; 19 (9) . https://dx.doi.org/10.2174/1381612811319090015
DOI https://dx.doi.org/10.2174/1381612811319090015 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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