Abstract
From the onset to the healing stage of acute coronary syndromes, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Even though the early reperfusion treatment either by thrombolysis or percutaneous coronary intervention provides the excellent clinical benefits in patients with acute coronary syndromes, ischemia/ reperfusion injury may somewhat offset those great advantages. Inflammation, although potentially protective, has been deeply associated with those detrimental conditions. The hexagonal vascular inflammatory network which is composed of activated various leukocytes, vascular endothelial cells, vascular smooth muscle cells, platelets, excess reactive oxygen species, and cholesterol may contribute these vicious circles. To address these complex syndromes with more benefits regarding the prevention and treatment, this review comprehensively updates the pathogenesis of acute coronary syndromes from the view points of vascular inflammation.
Keywords: acute coronary syndromes, inflammation, leukocyte, vascular endothelial cell, vascular smooth muscle cell, platelet, cholesterol, reactive oxygen species, cross-talk mechanisms, C-reactive protein
Current Pharmaceutical Design
Title:Acute Coronary Syndromes as Auto-Inflammatory Disorders
Volume: 18 Issue: 28
Author(s): Makoto Suzuki
Affiliation:
Keywords: acute coronary syndromes, inflammation, leukocyte, vascular endothelial cell, vascular smooth muscle cell, platelet, cholesterol, reactive oxygen species, cross-talk mechanisms, C-reactive protein
Abstract: From the onset to the healing stage of acute coronary syndromes, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Even though the early reperfusion treatment either by thrombolysis or percutaneous coronary intervention provides the excellent clinical benefits in patients with acute coronary syndromes, ischemia/ reperfusion injury may somewhat offset those great advantages. Inflammation, although potentially protective, has been deeply associated with those detrimental conditions. The hexagonal vascular inflammatory network which is composed of activated various leukocytes, vascular endothelial cells, vascular smooth muscle cells, platelets, excess reactive oxygen species, and cholesterol may contribute these vicious circles. To address these complex syndromes with more benefits regarding the prevention and treatment, this review comprehensively updates the pathogenesis of acute coronary syndromes from the view points of vascular inflammation.
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Cite this article as:
Suzuki Makoto, Acute Coronary Syndromes as Auto-Inflammatory Disorders, Current Pharmaceutical Design 2012; 18 (28) . https://dx.doi.org/10.2174/138161212802481228
DOI https://dx.doi.org/10.2174/138161212802481228 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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