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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

一组以医院为基础的轻度认知障碍类型的轻度帕金森综合征的横断面研究

卷 16, 期 7, 2019

页: [633 - 649] 页: 17

弟呕挨: 10.2174/1567205016666190726100744

价格: $65

摘要

背景：轻度帕金森氏症（MPS）与轻度认知障碍（MCI）类型相关，结果相互矛盾。 目的：使用logistic岭回归分析研究单个MPS与不同MCI类型的关联，并评估每种MCI类型，MPS与尾状萎缩，整体性脑萎缩以及以及白质高信号(WMH)和腔隙的地形位置。 方法：对1,168名年龄在45-97 (70,52 �} 9,41) 岁的不同类型MCI的受试者进行了横断面研究，他们接受了脑部MRI检查。 通过两个视觉评级量表对WMH进行了评估。 还评估了腔隙的数量和位置。 用双层比和侧脑室与大鼠脑的比值来评价尾状核萎缩和全脑萎缩。还评估了载脂蛋白E（APOE）基因型。 使用帕金森综合症评分量表的运动部分中的项目，评估了震颤，僵硬，运动迟缓以及步态/平衡/轴向功能障碍。 结果：运动迟缓和步态/平衡/轴向功能障碍是MPS最常遇到的，其次是僵硬和震颤。 MPS同时存在于健忘性和非健忘性MCI类型中，并与WMH，腔隙，双颚比和侧脑室与脑的比率相关。 结论：MPS存在于记忆删除和非记忆MCI类型中，尤其是在那些多个域中，并带有APOE ε4 等位基因。 皮质和皮质下的血管和萎缩过程有助于MPS。 需要长期的前瞻性研究来确定MPS对从MCI转化为痴呆的贡献。

关键词: 轻度帕金森病征，轻度认知障碍类型，白质高信号，腔隙，尾状萎缩，全脑萎缩。

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