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Review Article

小型活化RNAs对结直肠癌的治疗潜力

卷 19, 期 3, 2019

页: [140 - 146] 页: 7

弟呕挨: 10.2174/1566523219666190708111404

价格: $65

摘要

小型双链RNA已被公认为基因表达的主要调控因子。与进化保守的RNA干扰机制会降解或抑制靶标mRNA的翻译相反，小型激活RNA（saRNA）通过与RNAi类似的机制以靶标依赖性方式激活特定基因。最近，在癌症研究中已经广泛研究了saRNA介导的特定基因的表达调控。由于CRC的高发生率，最令人感兴趣的是RNA介导的基因激活在结直肠癌（CRC）发展中的应用。在这篇综述中，我们总结了当前有关saRNA介导的基因激活及其潜在机制的知识。此外，我们强调了利用saRNA诱导的基因表达作为结直肠癌研究中的研究工具的优势。最后，讨论了将saRNA应用于大肠癌的潜在疗法的可能性和挑战。

关键词: 小型非编码RNA，小型活化RNA，结直肠癌，治疗剂，siRNA，microRNA。

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