Strategies for In Vivo siRNA Delivery in Cancer

Title: Strategies for In Vivo siRNA Delivery in Cancer

Volume: 8 Issue: 3

Author(s): Anil K. Sood, Angela Sanguino and Gabriel Lopez-Berestein

Affiliation:

Keywords: SiRNA sequences, polyethylene glycol, folate receptor, Antibodies, Positively charged polymers

Abstract: A better understanding of the mechanisms involved in small interference RNA (siRNA) gene silencing opens new horizons for the development of the targeted therapy of malignant and benign diseases. As a research tool, siRNA has proven to be highly effective in silencing specific genes and modulating intracellular signaling pathways. However, systemic delivery of siRNA has been more problematic due to degradation and poor cellular uptake. In order to overcome these limitations, a variety of strategies are being developed including new delivery vehicles and chemical modifications. Here, we review potential approaches for the systemic delivery of siRNA for cancer treatment.

Cite this article as:

Sood K. Anil, Sanguino Angela and Lopez-Berestein Gabriel, Strategies for In Vivo siRNA Delivery in Cancer, Mini-Reviews in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/138955708783744074