An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin

Title:An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin

Volume: 14 Issue: 5

Author(s): Md. Habban Akhter and Saima Amin*

Affiliation:

• Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062,India

Keywords: Chemotherapy, drug targeting, molecular pathways, nanoparticles, skin, receptors, squamous cell carcinoma.

Abstract: Background: Squamous cell carcinoma of skin has become an important matter of discussion worldwide due to high number of deaths. Treatment of such cancer involves use of drugs (chemotherapy) along with surgery or radiation therapy. The combination chemotherapy is preferred over single treatment modality may be due to synergistic effect of targeting agent resulting in reduced drug dose, reduced cytotoxic effect and improved efficacy and survival rate. The objective of this work is to provide insight into the squamous cell carcinoma of skin; the various approaches and challenges adapted to surmount the cancer malignancies.

Methods: Research evidence shows that nanoparticle based therapeutic delivery to squamous cell carcinoma is equanimous to lead therapeutic approaches for intervention of cancer growth. Active chemotherapeutic approach is one of the leading therapies to such cancer cells due specific selectivity towards the EGFR-receptors over-expressed in tumor cells. Review of numerous research publications revealed innate toxicity of chemotherapeutic agents, and substantiated active receptor mediated drug targeting for therapeutic regime. These actively functionalized nanoparticles have been delivered to the targeted cells with higher selectivity, minimal toxicity and better retention in the cell.

Results: Numerous approaches and strategies have been designed till date for successful delivery of drug to cancer cells. The techniques have shown tremendous improvement in getting normalcy of carcinomas but a few have been marketed so far.

Conclusion: Indeed, receptor based drug targeting approach through molecular signal transduction pathways involved in skin cancer development will provide insight into squamous carcinoma. Despite of these, other such challenges in drug delivery to squamous cell carcinoma need further clarification.

Cite this article as:

Akhter Habban Md. and Amin Saima*, An Investigative Approach to Treatment Modalities for Squamous Cell Carcinoma of Skin, Current Drug Delivery 2017; 14 (5) . https://dx.doi.org/10.2174/1567201801666160906104254

DOI https://dx.doi.org/10.2174/1567201801666160906104254	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704