Clinical Considerations of Focal Drug Delivery in Cancer Treatment

Title:Clinical Considerations of Focal Drug Delivery in Cancer Treatment

Volume: 14 Issue: 5

Author(s): Jamie Harris, Samuel C. Klonoski and Bill Chiu*

Affiliation:

• Department of Surgery, University of Illinois at Chicago, 840 S. Wood Street, Suite 416, Chicago, IL 60612,United States

Keywords: Chemotherapy, local drug delivery, metastasis, radiation, resection, solid tumor.

Abstract: Background: According to the US Center for Disease Control, cancer deaths are the second most common cause of mortality in both adults and children. Definitive treatment of solid tumors involves surgical resection with or without systemic chemotherapy and radiation. The advent of local drug delivery presents a unique treatment modality that can offer substantial benefits in cancer management. Three main phases in solid tumor management exist for the treating physician: initial diagnosis with tissue biopsy, surgical resection with or without chemotherapy, and management of metastatic disease.

Methods: A literature review of both basic science as well as clinical trials using local drug delivery strategies in the management of solid tumors was done on PubMed. These were then further divided into the categories of initial tissue biopsy intervention, surgical resection, and management of metastatic disease.

Results: A total of 27 articles were review that included both pre-clinical as well as clinical investigation of local drug delivery therapies in the treatment of solid tumors. Treatments such as MRI guided therapies, FDA approved local therapies for intracranial gliomas as well as local therapy for single site metastatic disease were identified.

Conclusion: This review focuses the current state of local drug delivery in the treatment of solid tumors in both the pre-clinical as well as clinical investigation settings. Local drug delivery therapy offers an exciting new treatment modality for solid malignancies.

Cite this article as:

Harris Jamie, Klonoski C. Samuel and Chiu Bill*, Clinical Considerations of Focal Drug Delivery in Cancer Treatment, Current Drug Delivery 2017; 14 (5) . https://dx.doi.org/10.2174/1567201814666170224143706

DOI https://dx.doi.org/10.2174/1567201814666170224143706	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704