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Review Article

具有抗癌活性和最小细胞毒性价值的药用植物研究现状与展望

卷 20, 期 12, 2019

页: [1227 - 1243] 页: 17

弟呕挨: 10.2174/1389450120666190429120314

价格: $65

摘要

癌症是全球发病率和死亡率的第二大原因。虽然化疗和放疗提高了癌症患者的生存率，但它们有几种急性毒性作用。因此，需要寻找具有更好功效和更小副作用的新抗癌剂。在这方面，发现草药治疗是治疗和预防癌症的安全方法。在这里，已经尝试筛选一些较少探索的药用植物，如Ammania baccifera，Asclepias curassavica，Azadarichta indica，Butea monosperma，Croton tiglium，Hedera nepalensis，Jatropha curcas，Momordica charantia，Moringa oleifera，Psidium guajava等具有强效抗癌药物。细胞毒性值最小（IC50>3μM），毒性较小或可忽略不计的活性。它们富含活性植物化学物质，具有广泛的药物靶标。在该研究中，通过体外MTT测定和体内肿瘤模型以及一些据报道具有0.019-0.528mg / ml范围内IC50值的植物评估这些药用植物的剂量依赖性细胞毒学研究。该发现表明这些植物通过其抗增殖，促凋亡，抗转移和抗血管生成分子靶标来抑制肿瘤生长。它们被广泛使用，因为它们易于获得，价格合理且没有或有时副作用很小。本综述为从药用植物中发现抗癌药物提供了基线，这些药物具有最小的细胞毒性值，副作用最小，并为人类福祉建立了类似物。

关键词: 抗癌植物，IC50，植物化学物质，细胞毒性，MTT测定，化学疗法。

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