Abstract
Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also been highlighted.
Keywords: Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide
Mini-Reviews in Organic Chemistry
Title:Natural Products Based Anticancer Agents
Volume: 9 Issue: 2
Author(s): Biswanath Das and Gandham Satyalakshmi
Affiliation:
Keywords: Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide
Abstract: Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also been highlighted.
Export Options
About this article
Cite this article as:
Das Biswanath and Satyalakshmi Gandham, Natural Products Based Anticancer Agents, Mini-Reviews in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157019312800604706
DOI https://dx.doi.org/10.2174/157019312800604706 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cadmium and Its Epigenetic Effects
Current Medicinal Chemistry Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems
Current Pharmaceutical Biotechnology Multicolor-FISH Approaches for the Characterization of Human Chromosomes in Clinical Genetics and Tumor Cytogenetics
Current Genomics Overview of Mechanisms of Cancer Stem Cell Drug Resistance
Current Signal Transduction Therapy Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery
Current Drug Targets Enzyme / Abzyme Prodrug Activation Systems: Potential Use in Clinical Oncology
Current Pharmaceutical Design miRNAs Highlights in Stem and Cancer Cells
Mini-Reviews in Medicinal Chemistry Aminophosphonate Metal Complexes of Biomedical Potential
Current Medicinal Chemistry New Anti-Cancer Strategies in Testicular Germ Cell Tumors
Recent Patents on Anti-Cancer Drug Discovery Angiogenesis Markers in Gynecological Tumors and Patents for Anti- Angiogenic Approach: Review
Recent Patents on Anti-Cancer Drug Discovery Role of Renin-Angiotensin System in Vascular Endothelial Dysfunction of Pregnancy-Induced Hypertension
Current Hypertension Reviews The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Current Pharmaceutical Design Identification of Disease-Relevant Genes for Molecularly-Targeted Drug Discovery
Current Cancer Drug Targets An overview of ABC and SLC Drug Transporter Gene Regulation
Current Drug Metabolism Anticancer Drug-Induced Immunomodulation and Cancer Therapeutics
Current Cancer Therapy Reviews Recent Developments of Steroid Sulfatase Inhibitors as Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry Passive Targeting of Cyclophosphamide-Loaded Carbonate Apatite Nanoparticles to Liver Impedes Breast Tumor Growth in a Syngeneic Model
Current Pharmaceutical Design Membrane and Soluble Forms of Endoglin in Preeclampsia
Current Molecular Medicine Negative Glucocorticoid Receptor Response Elements and their Role in Glucocorticoid Action
Current Pharmaceutical Design Transcriptional Control of Collagen I Gene Expression
Cardiovascular & Hematological Disorders-Drug Targets