Abstract
Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.
Keywords: Cancer, leptin, estrogen receptors
Mini-Reviews in Medicinal Chemistry
Title: Leptin, Estrogens and Cancer
Volume: 6 Issue: 8
Author(s): Maria del Carmen Maeso Fortuny, Buenaventura Brito Diaz and Antonio Cabrera de Leon
Affiliation:
Keywords: Cancer, leptin, estrogen receptors
Abstract: Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.
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Cite this article as:
Maeso Fortuny Maria del Carmen, Brito Diaz Buenaventura and Cabrera de Leon Antonio, Leptin, Estrogens and Cancer, Mini-Reviews in Medicinal Chemistry 2006; 6 (8) . https://dx.doi.org/10.2174/138955706777934973
DOI https://dx.doi.org/10.2174/138955706777934973 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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