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Research Article

MiR-125b作为I期肺腺癌潜在生物标志物的诊断价值

卷 19, 期 3, 2019

页: [216 - 227] 页: 12

弟呕挨: 10.2174/1566524019666190314113800

价格: $65

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摘要

背景：我们的目的是探索致癌过程中差异表达的miRNA的生物学功能，鉴定参与DNA修复机制的miRNAs dysegulations，并评估miRNA作为早期肺腺癌（LAC）的预后和诊断生物标志物的潜力。 方法：我们获得了21例LAC和配对的邻近正常福尔马林固定，石蜡包埋的肺组织，这些患者接受了I期LAC的根治性切除术。我们比较了LAC与邻近组织之间DNA修复机制中涉及的8种miRNA的表达水平。 结果：Hsa-miR-9-5p，hsa-miR-24-3p，hsa-miR-125a-3p，hsa-miR-125b-5p，hsa-miR-155-5p和hsa-let-7a的表达与邻近组织相比，I期LAC组织中-5p显着上调。此外，hsa-mir-9-5p，hsa-mir-24-3p，hsa-mir-125a-3p，hsa-mir-125b-5p和hsa-mir-155-5p的表达显着上调。在阶段Ia LAC组织中，而hsa-mir-125a-3p和hsa-mir-125b-5p的表达在Ib阶段LAC组织中显着上调。受试者工作特征（ROC）分析显示hsa-mir-125b-5p的AUROC为0.875（P <0.001）。 结论：hsa-mir-125b-5p的表达可用于区分LAC与邻近组织。我们的结果表明hsa-mir125b-5p可以作为LAC的预后和诊断生物标志物。

关键词: 癌，非小细胞肺癌，腺癌，Micro RNA，Mir-125b，生物标志物。

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