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Review Article

TRP通道在过敏性炎症中的作用及其临床意义

卷 27, 期 9, 2020

页: [1446 - 1468] 页: 23

弟呕挨: 10.2174/0929867326666181126113015

价格: $65

摘要

过敏是指对非传染性环境物质（过敏原）的异常适应性免疫反应，可诱发多种疾病，例如哮喘，特应性皮炎和过敏性鼻炎。在这种变态反应性炎症中，涉及各种免疫细胞，例如B细胞，T细胞和肥大细胞，并经历复杂的相互作用，从而导致各种病理生理状况。在免疫细胞中，钙离子在控制细胞内Ca2 +信号通路中起着至关重要的作用。阳离子（例如Na +）通过调节细胞膜电位来间接调节钙信号的产生。这种细胞内Ca2 +信号传导是通过各种阳离子通道介导的。其中，几乎所有的免疫细胞类型都存在瞬时受体电位（TRP）家族，每个通道在调节Ca2 +信号方面具有独特的功能。在这篇综述中，我们关注TRP离子通道在T细胞和肥大细胞过敏性炎症反应中的作用。另外，讨论了在变应性疾病的临床实践中引起关注的TRP离子通道，以及靶向TRP通道的治疗剂的开发现状。

关键词: 细胞，TRP通道，过敏性鼻炎，哮喘，特应性皮炎，钙信号，肥大细胞..

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