The Potential of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligands in the Treatment of Hematological Malignancies

C.      Ulivieri; C.   T.   Baldari

doi:10.2174/138955707781662618

Abstract

PPARγ has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands. Here we shall review the activities of PPARγ ligands in the control of immune cell proliferation, differentiation and apoptosis and their potential therapeutic applications to hematological malignancies.

Keywords: PPARγ ligands, cancer, immune system, cell cycle, apoptosis, TZDs, myeloid neoplasms, lymphoid neoplasms