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Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

NEDD4: A Promising Target for Cancer Therapy

Author(s): Xiantao Ye, Lixia Wang, Bingxue Shang, Zhiwei Wang and Wenyi Wei

Volume 14, Issue 6, 2014

Page: [549 - 556] Pages: 8

DOI: 10.2174/1568009614666140725092430

Price: $65

Abstract

The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.

Keywords: Cancer, E3 ligase, NEDD4, oncogene, target, therapy, ubiquitination.

Graphical Abstract


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