摘要
倍半萜内酯，植物的次级代谢产物，存在于大量来自Asteracea家族的物种中，在许多国家的传统医学中用于治疗各种病理状况。他们发挥广泛的活动，包括抗炎，抗菌和抗癌特性。已经用作药物或用于临床试验的最着名的倍半萜烯内酯是青蒿素，毒胡萝卜素和小白菊内酯。另一种倍半萜内酯，helenalin，山金车的一种活性成分，以其强大的抗炎活性而闻名，几个世纪以来一直用于民间医学治疗轻微损伤。不幸的是，helenalin引起过敏反应的能力及其对健康组织的毒性迄今为止阻止了这种倍半萜内酯作为抗癌药或抗炎药的开发。最近，已经观察到对生物学特性以及合成helenalin类似物的新兴趣。本综述介绍了helenalin的主要生物活性，分子作用机制，其毒性和进一步研究的潜力。
关键词: 天然产物，NF-κB，端粒酶，细胞凋亡，合成类似物，癌症，原生动物。
图形摘要
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