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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Novel Chemotherapeutic Agents - The Contribution of Scorpionates

Author(s): Marta A. Andrade and Luísa M.D.R.S. Martins*

Volume 26, Issue 41, 2019

Page: [7452 - 7475] Pages: 24

DOI: 10.2174/0929867325666180914104237

Price: $65

Abstract

The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

Keywords: Scorpionate, metal complexes, cytotoxic agents, carbon oxide releasing molecules (CORMs), photosensitizers, chemotherapeutic agents.

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