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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Pharmacological Effects and Chemical Constituents of Bupleurum

Author(s): Peng Sun, Yijie Li, Sheng Wei, Tingting Zhao, Yang Wang, Chunhong Song, Ling Xue, Fushun Wang, Lingyun Xiao, Jibiao Wu and Mingqi Qiao*

Volume 19, Issue 1, 2019

Page: [34 - 55] Pages: 22

DOI: 10.2174/1871520618666180628155931

Price: $65

Abstract

Radix Bupleuri has been used in traditional Chinese medicine for thousands of years, with confirmed curative effects. This plant is also used in healthy food and cosmetics. A recent increase in studies of Radix Bupleuri’s chemical constituents (mainly comprising flavonoids, lignins, phenyl propanol derivatives, triterpenoid saponins, and volatile oils) and pharmacological effects motivates the aim of the present study: to review the chemical components and pharmacological effects of Radix Bupleuri. Our review found that Radix Bupleuri exhibits diverse pharmacological effects. More than 281 components have been isolated from Radix Bupleuri, including 15 flavonoids, 430 lignins, 12 phenyl propanol derivatives, 66 triterpenoid saponins, and 158 volatile oils.

Keywords: Radix Bupleuri, pharmacological action, chemical composition, Chinese medicine, flavonoids, phenyl propanol derivatives, triterpenoid saponins, volatile oils.

Graphical Abstract

[1]
Hare, J.I.; Lammers, T.; Ashford, M.B.; Puri, S.; Storm, G.; Barry, S.T. Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. Adv. Drug Deliv. Rev., 2017, 108, 25-38.
[2]
Komiyama, M.; Yoshimoto, K.; Sisido, M.; Ariga, K. Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics. Bull. Chem. Soc. Jpn., 2017, 90(9), 967-1004.
[3]
Anselmo, A.C.; Mitragotri, S. Impact of particle elasticity on particle-based drug delivery systems [J]. Adv. Drug Deliv. Rev., 2017, 108, 51-67.
[4]
Kitaoka, C.; Asano, T.; Fujino, T. Direct measurement and quantification of drugs and their metabolites in urine by MALDI-MS using zeolite. Bull. Chem. Soc. Jpn., 2017, 90(2), 154-160.
[5]
Ariga, K.; Minami, K.; Ebara, M. What are the emerging concepts and challenges in NANO[quest] Nanoarchitectonics, hand-operating nanotechnology and mechanobiology. Polym. J., 2016, 48(4), 371-389.
[6]
Chinese Pharmacopoeia Commission. Pharmacopeia of the people’s Republic of China[S]. Beijing: China Medical Science Press,. 2015; pp.280-281.
[7]
Qian, Y.; Wu, Z.J. Anti-infection and anti-pyretic effect of minor dicoction of Bupleurum: An experimental study. Chin. J. Nosocomiol., 2008, 18(4), 576-578.
[8]
Yang, Z.G.; Chen, A.Q.; Sun, H.X. Research progress on pharmacological action of Radix Bupleuri. China J. Veterin. Med, 2005, 39(5), 27-30.
[9]
Qian, Y.; Wu, Z. Experimental study on the anti-infection and antipyretic effect of Xiao Chaihu Decoction. Chin. J. Nosocom. Infect, 2008, 18(4), 576-578.
[10]
Xue, Y.; Bai, J.Y. Comparative study on Antipyretic constituents of Radix Bupleuri. Pharmacol. Clin. Chin. Mat. Med, 2003, 19(1), 11-12.
[11]
Xie, D.H.; Cai, B.C.; An, Y.Q. Advances in research on chemical constituents and pharmacological effects of Bupleurum saponins. J. Nanjing Univ. Chin. Med., 2007, 23(1), 63-65.
[12]
Zhu, L.X.; Liu, S.Z.; Gu, Z.L. Pharmacological effects of Bupleurum chinense and its application in anti hepatic fibrosis. Chin. Tradit. Herbal Drugs, 2002, 33(10)
[13]
Zu, N.; Li, P. Physiological effects of Bupleurum saponin and its clinical significance. Chin. J. Info. Tradit. Chin. Med, 2005, 12(4), 94-96.
[14]
Li, Y. Experimental study of the effect of Xiao Chaihu Decoction and its disassembled side on influenza virus in vitro [D]. Hubei Univ. Chin. Med., 2010.
[15]
Bai, Z.; Wang, Y.; Jia, T. Research Progress on the pharmacological action of Bupleurum Bupleurum[C]. Member congress of Chinese medicine processing branch of Chinese Medicine Association. 2007.
[16]
Chen, J.; Duan, M. Zhao, Ling, F.; Xiao, K.; Li, Q.; Li, B.; Lu, C.; Qi, W.; Zeng, Z.; Liao, M.; Liu, Y.; Chen, W. Saikosaponin A inhibits influenza A virus replication and lung immunopathology. Oncotarget, 2015, 6(40), 42541-42556.
[17]
Zhang, Y. Clinical observation on treatment of 56 cases of mumps with Bupleurum and Ribavirin injection. Tianjin J. Tradit. Chin. Med., 2000, 17(3), 45-48.
[18]
Liao, J.P.; Chen, Y. To observe the clinical curative effect of ribavirin plus Zijinding on mumps. Jiangxi J. Tradit. Chin. Med., 2002, 33(4), 44-47.
[19]
Huang, W.; Zhao, Y.; Sun, R. Research progress of hepatoprotective effect and hepatotoxicity of Bupleurum chinense. Chin. J. Pharmacovigil., 2011, 8(1), 38-41.
[20]
Zhan, X.J.; Cai, P.; Liu, X.F. Effects of total flavonoids from Bupleurum chinense on ANIT induced intrahepatic cholestasis in rats. Chin. Pharmacol. Bull, 2010, 26(6), 780783.
[21]
Luo, L.; Wu, H.L.; Ji, P. Total flavonoids from the Bupleurum smithii Wolff var. Parvifolium alleviates α-naphthyl isothiocyanate-induced liver injury with acute jaundice in rats. Chin. J. Biochem. Mol. Biol., 2012, 28(10), 946-951.
[22]
Song, X.; Ren, T.; Zhou, Z. Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway. Int. J. Biol. Macromol., 2017, 95, 357-362.
[23]
Hu, S.C.; Lee, I.T.; Yen, M.H. Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d. J. Ethnopharmacol., 2016, 179, 432-442.
[24]
Xia, W.; Cui, X.Y.; Cui, Q.Y. Inhibitory effect of Saikosaponin d(SSd)on proliferation of K562 cells. J. Beihua Univ. Nat. Sci., 2002, 3(2), 113-115.
[25]
Wang, Y.L.; He, S.X.; Luo, J.Y. Progress in research on antitumor activity of saikosaponin and its mechanism. J. Integr. Med., 2006, 4(1), 98-100.
[26]
Shen, X.; Zhao, Z.Y. Research progress of Bupleurum active constituents and pharmacological effect on liver complaint. World Biotechnol., 2014, 2, 100.
[27]
Huang, W.; Sun, R. Advances in research on saikosaponin chemical constituents and pharmacological and toxicological effects. Pharmacol. Clin. Chin. Mat. Med., 2010, 71-74.
[28]
Wang, Y.X. Y.X.; Liu, Q.Y.; Zhang, M. Polysaccharides from Bupleurum Induce Immune Reversal in Late Sepsis [J]. Shock, 2017.
[29]
Yen, M.H.; Lin, C.C.; Yen, C.M. The immunomodulatory effect of saikosaponin derivatives and the root extract of Bupleurum kaoi in mice [J]. Phytother. Res., 2010, 9(5), 351-358.
[30]
Xu, S.M.; Zheng, K.J.; He, J.Y. Modulation of electrical activity on epilepsy model by Bupleurum chinense. Can. J. Appl. Physiol., 2002, 18(3), 294-296.
[31]
Yang, Z.G.; Chen, A.Q.; Sun, H.X. Research progress on pharmacological action of Radix Bupleuri. China J. Veterin. Med, 2005, 39(5), 27-30.
[32]
Liu, Y.; Liao, W.P.; Gao, M.M. Experimental study on anticonvulsant effect of extracts from Radix Bupleuri. J. New Chin. Med, 2001, 33(9), 76-77.
[33]
An, Y.M.; Jie, C.Y. Research progress of Bupleurum chinense. Ginseng Res, 2001, 13(1), 12-14.
[34]
Tang, W.J.; Lu, X.H.; Zhou, D.X. Study on analgesic effect of Bupleurum chinense. Hunan J. Tradit. Chin. Med., 2003, 52-53.
[35]
Chen, Y.; Su, S. Research Progress on chemical constituents and pharmacological effects of Bupleurum. Heilongjiang Med. J., 2014, 3, 630-633.
[36]
Huang, W.; Lv, Z.; Sun, R. Research Development on chemincal compositions in bupleurum chinense related with efficacy and toxicity [J]. Chin. J. Pharmacovigil, 2013, 10(09), 545-548.
[37]
Wo, Y.; Yao, L.; Su, S. Progress of Chemical Constituents of Bupleurum Chinese [J]. Heilongjiang Med. J., 2011, 24(2), 215-217.
[38]
Zhou, Y.; Wang, Y.; Ma, Z. Chromatographic fingerprint analysis of Bupleuri Radix by HPLC-ELSD [J]. J. Chin. Pharm. Sci., 2013, 22(1), 40-46.
[39]
Sun, B. Study on the chemical composition and antianaphylaxis of Bupleurum chinensis; Shenyang Pharmaceutical University, 2005. D
[40]
Tang, Z. Study on the chemical composition and quality of Bupleurum chinensis [D]. Beijing Univ. Chin. Med, 2010.
[41]
Zhu, L.; Liang, Z.T.; Yi, T.; Ma, Y.; Zhao, Z-Z.; Guo, B-L.; Zhang, J-Y. Hu-Biao. Comparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach [J]. Bmc Complement. Alternat. Med, 2017, 17(1), 305.
[42]
Xu, N.; Shi, Y.N.; Zhong, X.; Cao, Y.; Wang, L.; Jia, T-Z. A new saikogenin from the roots of Bupleurum bicaule [J]. Chin. J. Nat. Med., 2014, 12(4), 305.
[43]
Sun, Z.; Lv, X.; Xu, G.; Su, R.; Zhao, Z. Chemical constituents of volatile oil from different parts of Bupleurum chinense in gansu by GC-MS [J]. Chin. J. Experiment. Tradit. Med. Formul, 2012, 18(9), 75-78.
[44]
Li, X.Q.; Sun, X.Y.; He, Z.G. Study on extraction method of volatile oil from Bupleurum chinense. Chin. Pharmaceut. J., 2004, 39(2), 103-105.
[45]
Liu, Y.F.; Yan, Y.N.; Liu, Y.H. Supercritical fluid extraction of essential oil from Bupleurum chinense and its chemical composition analysis. Chin. Arch. Tradit. Chin. Med., 2005, 23(4), 663-665.
[46]
Liu, Y.F.; Yan, Y.N.; Liu, Y.H. GC-MS analysis of volatile oil from Bupleurum Fruits. Chin. Tradit. Herbal Drugs, 2005, 36(5), 671-672.
[47]
Shi, Z.; Chen, R.; Chen, Y. Study on the chemical composition of the essential oil extracted from Bupleuri chinese by different methods. [J]. J. Nanjing Univ. Tradit. Chin. Med., 2015, 31(06), 576-578.
[48]
Ge, F.H.; Li, Y.; Xie, J.M. Study on supercritical CO2 extraction of volatile oil and its saponins from Bupleurum chinense. China J. Chin. Mat. Med., 2000, 25(3), 149-153.

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