Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat

Title:Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat

Volume: 17 Issue: 5

Author(s): Tahereh Farkhondeh, Saeed Samarghandian*, Fariborz Samini and Ali Rajabpour Sanati

Affiliation:

• Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur,Iran

Keywords: Brain, behavior, crocetin, oxidative stress, restraint stress, inmobilization.

Abstract: Background & Objective: Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days. Findings showed that the immobility time significantly increased in the rodents subjected to the chronic stress compared with the normal group. However, the number of crossing beams in the rats submitted to the chronic stress significantly decreased versus the non-stress rats. Treatment with crocetin ameliorated the immobility time and the number of crossing in the chronic restraint stress rats versus the non-treated stress group. Crocetin also reverted the levels of MDA and GSH and also the activities of antioxidant enzymes to the normal levels in the stress groups.

Conclusion: The present study suggests that crocetin may be useful for the management of depressantlike effects induced by chronic stress through decreasing oxidative damage in the brain.

Cite this article as:

Farkhondeh Tahereh, Samarghandian Saeed*, Samini Fariborz and Sanati Rajabpour Ali, Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat, CNS & Neurological Disorders - Drug Targets 2018; 17 (5) . https://dx.doi.org/10.2174/1871527317666180515120212