Generic placeholder image

Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Mini-Review Article

Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions

Author(s): Fatima Zriek, John A. Di Battista and Nada Alaaeddine*

Volume 16, Issue 6, 2021

Published on: 02 February, 2021

Page: [656 - 669] Pages: 14

DOI: 10.2174/1574888X16666210202145639

Price: $65

Abstract

Mesenchymal stromal cells (MSCs) have emerged as a modern development in therapeutics for a wide variety of diseases. Secreted paracrine factors constitute the principal components harboring the restorative promise of MSCs. Recent studies demonstrate that MSC-derived secretomes are composed of several molecules targeting a variety of biological processes that impact tissue repair, growth and immunomodulation. Indeed, secretomes interact with immune cells, activating regulatory anti-inflammatory phenotypes. In this review, we discuss the action of MSC-derived secretomes in promoting tissue regeneration, opposing the inflammatory response in context-specific cases, and treating neurodegenerative diseases, resulting from chronic neuroinflammation.

Keywords: Mesenchymal stromal cells, secretome, conditioned medium, inflammation, regeneration, neurodegenerative diseases.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy