摘要
超声在医学领域的最初应用局限于对实体肿瘤的热消融,并作为诊断工具。最近在临床前阶段的进展已经允许使用超声波作为一种强有力的工具来改善药物的释放,当药物被包裹在纳米颗粒内时。这种药物释放的时空控制,利用一种非侵入性的方式,由于减少了抗肿瘤药物与健康组织的相互作用,是减少癌症治疗中常规化疗副作用的一种很有希望的方法。在这篇综述中,我们解释了超声波的物理原理,介绍和讨论了纳米粒子作为药物载体的几个例子,重点介绍了脂质体。介绍和讨论了体内和体外研究的实例。
关键词: 癌症,脂质体,药物传递,超声,药物释放,抗肿瘤药物。
Current Molecular Medicine
Title:Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
Volume: 17 Issue: 10
关键词: 癌症,脂质体,药物传递,超声,药物释放,抗肿瘤药物。
摘要: The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
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Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment, Current Molecular Medicine 2017; 17 (10) . https://dx.doi.org/10.2174/1566524018666180416100142
DOI https://dx.doi.org/10.2174/1566524018666180416100142 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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