Abstract
The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Current Molecular Medicine
Title:Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
Volume: 17 Issue: 10
Author(s): N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*
Affiliation:
- Department of Chemical Engineering, American University of Sharjah, Sharjah,United Arab Emirates
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Abstract: The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
Export Options
About this article
Cite this article as:
Salkho N.M., Turki R.Z., Guessoum O., Martins A.M., Vitor R.F. and Husseini G.A.*, Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment, Current Molecular Medicine 2017; 17 (10) . https://dx.doi.org/10.2174/1566524018666180416100142
DOI https://dx.doi.org/10.2174/1566524018666180416100142 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Clinical Applications of the Urokinase Receptor (uPAR) for Cancer Patients
Current Pharmaceutical Design The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated Diseases
Current Drug Targets Meet Our Editorial Board Member
Anti-Cancer Agents in Medicinal Chemistry Multifaceted Role of Neuropilins in Cancer
Current Medicinal Chemistry Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer
Current Medicinal Chemistry Is there Any Correlation Between Binding and Functional Effects at the Translocator Protein (TSPO) (18 kDa)?
Current Molecular Medicine A Bioinformatics Pipeline for Cancer Epigenetics
Current Bioinformatics Application of Phage Display Technology to Cancer Research
Current Pharmaceutical Biotechnology Gastric Carcinoma at the Era of Targeted Therapies
Current Drug Targets Stereoselective Pharmacodynamics and Pharmacokinetics of Proton Pump Inhibitors
Current Drug Metabolism Interrelationships Among Gut Microbiota and Host: Paradigms, Role in Neurodegenerative Diseases and Future Prospects
CNS & Neurological Disorders - Drug Targets Synthesis of Novel Fused Heterocyclic Compounds from 7-amino-[1,2,4]triazino[3,4- b][1,3,4]thiadiazine-8-carbonitrile
Current Organic Synthesis IP6 & Inositol in Cancer Prevention and Therapy
Current Cancer Therapy Reviews Recent Advances in Designing Substrate-Competitive Protein Kinase Inhibitors
Current Pharmaceutical Design Activating Mutations of ESR1, BRCA1 and CYP19 Aromatase Genes Confer Tumor Response in Breast Cancers Treated with Antiestrogens
Recent Patents on Anti-Cancer Drug Discovery Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions
Current Drug Metabolism Selective Matrix Metalloproteinase Inhibitors for Cancer
Current Medicinal Chemistry Editorial [Hot Topic: ErbB Family and Downstream Signal Transduction Pathways as Targets for Anticancer Therapy (Guest Editor: F. Caponigro)]
Current Drug Targets Withdrawal Notice: STK33-Dependent Transcriptional Regulation of SFTA3 Induces Cisplatin-Resistance in Lung Adenocarcinoma
Anti-Cancer Agents in Medicinal Chemistry DNA Methylation and Breast Cancer
Current Genomics