Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or İllusion?

Title:Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or İllusion?

Volume: 23 Issue: 43

Author(s): Melike Uner*, Sukran Damgali, Samet Ozdemir and Burak Celik

Affiliation:

• Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Beyazit 34116 Istanbul,Turkey

Keywords: Solid lipid nanoparticles, nanostructured lipid carriers, controlled drug delivery, colloidal drug carriers, stealth nanoparticles, targeting.

Abstract: Background: Solid lipid nanoparticles (SLN) are colloidal drug carrier systems that contribute several properties required from a sophisticated drug delivery system for increasing drug bioavailability and providing effective therapy. Many advantages of SLN have been reported over traditional dosage forms and their colloidal counterparts since the early 1990s. They were optimized for oral drug delivery for the first time. The first SLN formulations were produced by reducing particle size of solid lipid microparticles by spray congealing technique in the late 1980s. Then, studies have been continued investigating for their different administration routes else including parenteral, transdermal, ocular, nasal, respiratory etc.

Methods: Their foremost qualifications such as their biocompatible nature and high drug entrapment efficiency make them promising colloidal drug carrier systems for effective treatment of serious disasters like genetic disorders and cancer.

Conclusion: In this review, therapeutic potential of drug delivery of SLN and nanostructured lipid carriers (NLC, the second generation of SLN) are summarized considering researches and patents on their administration via different routes and their preparations in the pharmaceutical market.

Cite this article as:

Uner Melike *, Damgali Sukran , Ozdemir Samet and Celik Burak , Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or İllusion?, Current Pharmaceutical Design 2017; 23 (43) . https://dx.doi.org/10.2174/1381612823666171122110638