摘要
背景：氨基酸是各种生化途径中的必需成分。剥夺某些氨基酸是用于治疗氨基酸依赖性癌症的抗代谢物策略，其利用恶性细胞的受损代谢。一些研究集中于氨基酸降解酶的开发和临床前和临床评价，即L-天冬酰胺酶，L-蛋氨酸γ-裂解酶，L-精氨酸脱亚胺酶，L-赖氨酸α-氧化酶。因此，对癌细胞代谢的进一步研究可以定义控制肿瘤生长的可能靶标。 目的：本综述的目的是总结氨基酸代谢与癌症治疗之间关系的最新进展，特别关注拉斯帕拉金，L-蛋氨酸，L-精氨酸和L-赖氨酸降解酶及其制剂，成功用于治疗几种类型的癌症。 方法：我们对有关氨基酸降解酶的文献进行了结构化搜索。搜索的主要方面是体外和体内研究，关于在肿瘤学中应用这些酶的临床试验。 结果：大多数已发表的研究都涉及L-天冬酰胺酶特性，并用于癌症治疗。 L-精氨酸脱亚胺酶在晚期黑色素瘤和肝细胞癌的II期试验中显示出有希望的结果。其他酶，特别是Lmethionineγ-裂解酶和L-赖氨酸α-氧化酶，在体外和体内都是有效的。 结论：该评价的结果表明，基于氨基酸消耗的治疗可能具有癌症治疗的潜在应用，但需要进一步的临床研究以提供这些药剂的功效和安全性。
关键词: 氨基酸降解酶，L-天冬酰胺酶，L-蛋氨酸γ-裂解酶，L-精氨酸脱亚胺酶，L-赖氨酸α-氧化酶，癌症治疗，癌症治疗。
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