Recent Advances in Mesoporous Silica and Gold Based Nanovectors in Anticancer Drug Delivery System

Title:Recent Advances in Mesoporous Silica and Gold Based Nanovectors in Anticancer Drug Delivery System

Volume: 21 Issue: 23

Author(s): Imran Ali, Sofi Danish Mukhtar, Mohammad Nadeem Lone, Heyam Saad Ali and Hassan Y. Aboul-Enein

Affiliation:

Keywords: Mesoporous silica and gold based nanovectors in anticancer drug delivery, mechanisms of action, recent advances, current challenges, future prospective, tumors.

Abstract: Background: Advances in the medicinal nanotechnology have given upward thrust to multifunctional efficient nanocarriers that can be engineered with tunable physico-chemical traits to deliver one or extra healing agent(s) appropriately and selectively to the most cancers cells, focusing on intracellular organellespecific drug delivery.

Objective: Large pores of mesoporous silica nanoparticles allow the other particles to be filled with a drug through endocytosis. These emerge as highly attractive class of drug and gene delivery vectors. Gold nanoparticles

can also pack different sizes and several ligands, in order to gain function of targeting tumor cells.

Conclusion: In the present review, we compile the recent advances in mesoporous silica and gold nanoparticles as carriers of drugs and genes to tumors by passive and active approaches with descriptive examples. In addition, market status of mesoporous silica and gold based nanodrugs has been discussed. Finally, the efforts are made to discuss the current challenges and future prospectives.

Cite this article as:

Ali Imran, Mukhtar Danish Sofi, Lone Nadeem Mohammad, Ali Saad Heyam and Aboul-Enein Y. Hassan , Recent Advances in Mesoporous Silica and Gold Based Nanovectors in Anticancer Drug Delivery System, Current Organic Chemistry 2017; 21 (23) . https://dx.doi.org/10.2174/1385272820666161025161853