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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis and Anticancer Activity Evaluation of Diazepinomicin Derivatives

Author(s): Yongguo Yu, Jianbo Wu, Fan Lei, Lei Chen, Weili Wan, Li Hai, Mei Guan and Yong Wu

Volume 10, Issue 4, 2013

Page: [369 - 373] Pages: 5

DOI: 10.2174/1570180811310040011

Price: $65

Abstract

A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.

Keywords: Diazepinomicin, Derivatives, Synthesis, Anticancer


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