Abstract
A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.
Keywords: Diazepinomicin, Derivatives, Synthesis, Anticancer
Letters in Drug Design & Discovery
Title:Design, Synthesis and Anticancer Activity Evaluation of Diazepinomicin Derivatives
Volume: 10 Issue: 4
Author(s): Yongguo Yu, Jianbo Wu, Fan Lei, Lei Chen, Weili Wan, Li Hai, Mei Guan and Yong Wu
Affiliation:
Keywords: Diazepinomicin, Derivatives, Synthesis, Anticancer
Abstract: A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.
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Yu Yongguo, Wu Jianbo, Lei Fan, Chen Lei, Wan Weili, Hai Li, Guan Mei and Wu Yong, Design, Synthesis and Anticancer Activity Evaluation of Diazepinomicin Derivatives, Letters in Drug Design & Discovery 2013; 10 (4) . https://dx.doi.org/10.2174/1570180811310040011
DOI https://dx.doi.org/10.2174/1570180811310040011 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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