Review Article

心血管外科心房颤动 生物标志物确定预后

卷 26, 期 5, 2019

页: [916 - 924] 页: 9

弟呕挨: 10.2174/0929867324666170727104930

价格: $65

摘要

背景:心血管手术后新发心房颤动(AF)与并发症风险增加和住院时间延长有关。确定手术后房颤(POAF)高风险患者可能有助于采取具有临床和经济相关性的预防策略。 目的:本综述的重点是总结心肌纤维化生物标志物(PICP和PIIINP),促纤维化介质(TGF-β1),细胞外基质重塑(MMP-9),心肌舒张(BNP和NTpro-BNP),炎症的研究结果。 (白细胞介素,C-反应蛋白和sCD40L)和心肌坏死(高敏感肌钙蛋白T),生物标志物,可用于临床实践,对POAF风险患者进行分层。 方法:我们搜索了MEDLINE和PubMed的英语语言学习。证据综合基于队列研究,临床试验和荟萃分析数据。还审查了国际临床实践指南。 结果:心脏重塑,心房压力,手术创伤,炎症,氧化应激和交感神经/副交感神经激活等因素与POAF的发展有关。基于POAF发病的多因素机制,一些研究已经研究了一些血清生物标志物的预测价值。迄今为止,有关PICP,PIINP,TGF-β1和sCD40L的临床应用的有希望的初步数据,而关于NT-proBNP,BNP,CRP,IL-6和hs-cTnT的数据存在争议。 结论:尽管一些研究显示了有希望的结果,但在将生物标志物用作临床实践中POAF风险分层的工具之前,需要进行更长期随访的更大规模研究。

关键词: 心房颤动,术后心房颤动,胶原合成,脑利钠肽,白细胞介素,炎症。

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