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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

Author(s): Y. Cui and P. Madeddu

Volume 17, Issue 30, 2011

Page: [3271 - 3279] Pages: 9

DOI: 10.2174/138161211797904109

Price: $65

Abstract

Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.

Keywords: Stem cells, cardiovascular disease, ischemia, homing, signalling, repair, endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), chemokine, proteases


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