Synthetic Approaches to Various Class of Topoisomerase II Inhibitors

Title:Synthetic Approaches to Various Class of Topoisomerase II Inhibitors

Volume: 14 Issue: 5

Author(s): Sanal Dev*, Nishad Gabhe, S.R. Dhaneshwar, Monu Joy and Bijo Mathew

Affiliation:

• Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Perintalmanna, Kerala – 679325,India

Keywords: Topoisomerase II, etoposide, mitoxantrone, pharmacophoresm, podophyllotoxin, antineoplastic agent.

Abstract: Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitors in biological systems, it is vital to understand the fundamental organic chemistry of these inhibitory agents through various synthetic strategies and it is crucial for further developments of the same. Many of the reported TOP II inhibitors are associated with extreme structural complexities and require multi-step synthetic routes providing difficulties towards their preparation and modifications. The present work describes the synthetic protocols for a diverse array of candidates relating to both TOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.

Cite this article as:

Dev Sanal*, Gabhe Nishad , Dhaneshwar S.R. , Joy Monu and Mathew Bijo, Synthetic Approaches to Various Class of Topoisomerase II Inhibitors, Mini-Reviews in Organic Chemistry 2017; 14 (5) . https://dx.doi.org/10.2174/1570193X14666170518130301