摘要
石蒜在使治疗阿尔茨海默氏症药物的加兰他敏进入临床应用的药用植物中占有重要地位。由于石蒜科植物的一些生物碱成分表现出显著的抗增殖活性,这暗示了石蒜科植物中可能存在有抗癌药物。其中pancratistatin作为一种潜在的化疗试剂,已经进入了临床试验的不同阶段。石蒜科生物碱中lycorane和crinane也被发现存在有细胞毒性。虽然这些生物碱的分子靶点仍然难以确定,但在了解他们在癌细胞中作用机制方面已经做了大量的研究。最近研究表明,凋亡通路可能是石蒜生物碱诱导癌细胞凋亡的的关键因素。因此,本文旨在检测石蒜生物碱对癌细胞凋亡影响、探索该影响的分子机制并寻求该影响作用的药效原理。
关键词: 生物碱,石蒜科,细胞凋亡,癌症,细胞毒性机制。
Current Medicinal Chemistry
Title:Apoptosis-Inducing Effects of Amaryllidaceae Alkaloids
Volume: 23 Issue: 2
Author(s): Jerald J. Nair, Johannes van Staden and Jaume Bastida
Affiliation:
关键词: 生物碱,石蒜科,细胞凋亡,癌症,细胞毒性机制。
摘要: The Amaryllidaceae occupies a privileged status amongst medicinal plants in having delivered the Alzheimer’s drug galanthamine to the clinical market. Following its resounding success, there have been several positive indicators for the emergence of an anticancer drug from the family due to the potent antiproliferative activities manifested by several of its alkaloid constituents. Of these, the phenanthridones such as pancratistatin hold most promise as potential chemotherapeutics having succumbed to various phases of clinical trials. Other cytotoxic targets of the Amaryllidaceae are to be found within the lycorane and crinane groups, as exemplified by crinine and lycorine. Although the molecular targets of these alkaloids still remain elusive, much effort has gone into understanding their mode of action in cancer cells. Recent findings have shown that the apoptotic pathway may be a key factor in cancer cell death instigated by Amaryllidaceae alkaloids. As such, this review seeks to: (a) examine the apoptotic effects of Amaryllidaceae alkaloids in cancer cells; (b) explore the molecular basis to these effects; and (c) provide a pharmacophoric rationale in support of these activities.
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Cite this article as:
Jerald J. Nair, Johannes van Staden and Jaume Bastida , Apoptosis-Inducing Effects of Amaryllidaceae Alkaloids, Current Medicinal Chemistry 2016; 23 (2) . https://dx.doi.org/10.2174/0929867323666151118121124
DOI https://dx.doi.org/10.2174/0929867323666151118121124 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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