Abstract
In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.
Keywords: Diagnosis, ERG, prognosis, prediction, prostate carcinoma, TMPRSS2.
Graphical Abstract
Current Cancer Drug Targets
Title:Current State of ERG as Biomarker in Prostatic Adenocarcinoma
Volume: 15 Issue: 8
Author(s): Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady and A. Marcell Szasz
Affiliation:
Keywords: Diagnosis, ERG, prognosis, prediction, prostate carcinoma, TMPRSS2.
Abstract: In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.
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Cite this article as:
Acs Balazs, Szarvas Tibor, Szekely Nora, Nyirady Peter and Szasz Marcell A., Current State of ERG as Biomarker in Prostatic Adenocarcinoma, Current Cancer Drug Targets 2015; 15 (8) . https://dx.doi.org/10.2174/156800961508151001100829
DOI https://dx.doi.org/10.2174/156800961508151001100829 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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