ERG基因作为前列腺癌标志物的目前状态

Title:Current State of ERG as Biomarker in Prostatic Adenocarcinoma

Volume: 15 Issue: 8

Author(s): Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady and A. Marcell Szasz

Affiliation:

关键词: 诊断，ERG，预后，预报，前列腺癌，TMPRSS2

摘要: In this review we briefly discuss the possible biomarkers of prostate cancer among them we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas, we examine the incidence and detection of the most common genetic aberration in this tumor and its protein product as well. We also examined the correlation of clinicopathological factors and prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive markers.

Cite this article as:

Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady and A. Marcell Szasz , Current State of ERG as Biomarker in Prostatic Adenocarcinoma, Current Cancer Drug Targets 2015; 15 (8) . https://dx.doi.org/10.2174/156800961508151001100829