摘要
横纹肌肉瘤(RMS)是最常见的儿童软组织肿瘤,约占儿童恶性肿瘤的7%。标准治疗横纹肌肉瘤的多模式疗法一般不能治愈高风险组患者,并可能导致长期的副作用。因此,了解导致RMS的机制可能有助于找到新的、更具体和有效的治疗方法。导致肿瘤产生的一种分子机制是Hedgehog (Hh)信号途径。有越来越多的证据表明,Hedgehog (Hh)信号途径可能是治疗RMS的新方法。本文讨论了Hedgehog通路在治疗RMS的作用、在儿童中抑制这种胚胎信号的挑战以及正在进行的临床试验。
关键词: 小儿肿瘤、横纹肌肉瘤、发展途径、Hedgehog信号通路,小鼠模型,靶向治疗。
图形摘要
Current Drug Targets
Title:Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma
Volume: 17 Issue: 11
Author(s): Gabriele Manzella and Beat W. Schäfer
Affiliation:
关键词: 小儿肿瘤、横纹肌肉瘤、发展途径、Hedgehog信号通路,小鼠模型,靶向治疗。
摘要: Rhabdomyosarcoma (RMS) is the most frequent pediatric soft-tissue tumor accounting for about 7% of childhood malignancies. Multimodal therapy is the standard treatment for individuals with RMS but generally fails to cure high-risk group patients and can result in long-term side effects. Therefore, understanding the mechanisms driving RMS might help to find new candidate targets for more specific and effective therapeutic modalities. One of the molecular machineries which is often deregulated in cancer and specifically involved in tumorigenesis of RMS, is Hedgehog (Hh) signaling. There is increasing evidence that targeting this developmental pathway may hold promise in future treatment strategies for RMS. In this review, we discuss the contribution of the Hh pathway in RMS, the challenges of inhibiting this embryonic signaling in children with an update on recent preclinical data and ongoing clinical trials.
Export Options
About this article
Cite this article as:
Gabriele Manzella and Beat W. Schäfer , Interfering with Hedgehog Pathway: New Avenues for Targeted Therapy in Rhabdomyosarcoma, Current Drug Targets 2016; 17 (11) . https://dx.doi.org/10.2174/1389450116666150505122604
DOI https://dx.doi.org/10.2174/1389450116666150505122604 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fork Head Transcription Factors
Current Genomics Imaging Adoptive Cell Transfer Based Cancer Immunotherapy
Current Pharmaceutical Biotechnology Gut Homing Molecule Regulation of the Pathogenesis and Treatment of Inflammatory Bowel Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Inhibition of Polo-Like Kinase 1 by BI2536 Reverses the Multidrug Resistance of Human Hepatoma Cells In Vitro and In Vivo
Anti-Cancer Agents in Medicinal Chemistry Tailored Angiogenesis Inhibition in Cancer Therapy: Respecting the Heart to Improve the Net Outcome
Current Signal Transduction Therapy Exosome-like Nanovesicles Isolated from Citrus limon L. Exert Antioxidative Effect
Current Pharmaceutical Biotechnology Inhibitors of the Hedgehog Signal Transduction Pathway
Current Cancer Therapy Reviews Suramin: Clinical Uses and Structure-Activity Relationships
Mini-Reviews in Medicinal Chemistry The Scatter Factor Signaling Pathways as Therapeutic Associated Target in Cancer Treatment
Current Medicinal Chemistry Target Driven Preclinical Screening for New Antimitotic Chemotherapy Agents
Current Topics in Medicinal Chemistry Berberine Administration in Treatment of Colitis: A Review
Current Drug Targets Predicting the Druggability of Protein-Protein Interactions Based on Sequence and Structure Features of Active Pockets
Current Pharmaceutical Design The Functions of Histone Modification Enzymes in Cancer
Current Protein & Peptide Science Lactoferrin as a Natural Immune Modulator
Current Pharmaceutical Design Valproic Acid in the Complex Therapy of Malignant Tumors
Current Drug Targets The Critical Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis
Current Cancer Drug Targets Genetic Predisposition to Neonatal Tumors
Current Pediatric Reviews Neonatal Germ Cell Tumors
Current Pediatric Reviews Nitrogen Mustards as Anticancer Chemotherapies: Historic Perspective, Current Developments and Future Trends
Current Topics in Medicinal Chemistry From the Table to the Bedside: Can Food-Derived Sulforaphane be used as a Novel Agent to Treat Leukemia?
Current Cancer Drug Targets