摘要
脂泻病(CD)是一个自身免疫性疾病,由针对未消化的谷蛋白的自身免疫反应所诱导产生,其在人群中具有易发性。CD的病因与先天性适应性免疫相关,大多数由淋巴介导,尤其是T淋巴细胞,渗透到小肠壁。T细胞的亚型渗透到发炎的肠道组织中包含有各种CD4+和CD8+T细胞。剩余的T细胞亚型在CD中被激活,导致同时激活不同的信号通路群,包括GATA1、 NF-kB、JAK 或者 STAT5,这些通路的活度受饮食和药物的影响。最近的研究显示食品过敏源通过改变IL-15 和 CD4+ T和CD8+T细胞的相互作用而可能加剧CD。细胞因子如IL-15水平的增加在CD的发展过程中起着作用。并且,一些报道显示某些药物如tofacitinib或者ruxolitinib通过阻塞IL-15信号传导和CD8+T细胞活性从而影响CD。这篇简短的综述将对当前CD4+和CD8+T细胞在临床和试验上CD的作用,并将描述T细胞如何激活信号传导通路,以及饮食因素和治疗CD时的药物可能影响到局部蛋白质释放。
关键词: CD4+细胞,脂泻病,谷蛋白,HLA-DQ2,HLA-DQ8,信号通路,T细胞。
Current Drug Targets
Title:T Cell-Activated Signaling Pathways and Locally Produced Cytokines as Potential Targets in Celiac Disease
Volume: 16 Issue: 3
Author(s): Aleksandra Piechota-Polanczyk, Maciej Salaga and Ihor Huk
Affiliation:
关键词: CD4+细胞,脂泻病,谷蛋白,HLA-DQ2,HLA-DQ8,信号通路,T细胞。
摘要: Celiac disease (CD) is an autoimmune disease induced by an autoimmune reaction to indigested gluten, which occurs in genetically predisposed population. The etiology of CD is linked to innate and adaptive immunity, mostly mediated by lymphocytes, especially T cells, infiltrating into the small intestinal wall. The subpopulations of T cells that infiltrate inflamed intestinal tissues comprise various CD4+ T cells and CD8+ T cells. The plethora of T cell subtypes activated in CD leads to simultaneous activation of different signaling cascades including GATA1, NF-kB, JAK or STAT5 the activity of which may be modified by diet or drugs. It was recently showed that food allergens may accelerate CD by altering the interaction between IL-15 and CD4+ T cells in the activation of CD8+ T cells. Increased levels of cytokines like IL-15 are considered to play a role in CD development. Furthermore it was showed that some drugs like tofacitinib or ruxolitinib may influence CD by blocking IL-15 signaling and CD8+ T cell activity. This mini-review will summarize the current knowledge on the role of CD4+ T cell and CD8+ T cell in clinical and experimental CD and will describe how T cell-activated signaling pathways and locally released proteins may be influenced by dietary factors and drugs used in CD treatment.
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Aleksandra Piechota-Polanczyk, Maciej Salaga and Ihor Huk , T Cell-Activated Signaling Pathways and Locally Produced Cytokines as Potential Targets in Celiac Disease, Current Drug Targets 2015; 16 (3) . https://dx.doi.org/10.2174/1389450116666150304104627
DOI https://dx.doi.org/10.2174/1389450116666150304104627 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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